I Rubio Selected Research

ras Guanine Nucleotide Exchange Factors

1/2016

RasGRP1 overexpression in T-ALL increases basal nucleotide exchange on Ras rendering the Ras/PI3K/Akt pathway responsive to protumorigenic cytokines.

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I Rubio Research Topics

Disease

3	Neoplasms (Cancer) 01/2016 - 01/2001
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 04/2014 - 01/2003
2	Neoplasm Metastasis (Metastasis) 01/2001 - 01/2001
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/2016
1	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL) 01/2016
1	Lung Neoplasms (Lung Cancer) 04/2014
1	Necrosis 06/2012
1	Huntington Disease (Huntington's Disease) 06/2012
1	Neurodegenerative Diseases (Neurodegenerative Disease) 06/2012
1	Respiratory Tract Infections (Respiratory Tract Infection) 05/2010
1	Empyema 03/2001
1	Pneumonia (Pneumonitis) 03/2001
1	Adrenal Insufficiency (Adrenal Gland Hypofunction) 01/2001
1	Adenocarcinoma of Lung 01/2001
1	Goiter 01/2001

Drug/Important Bio-Agent (IBA)

2	ErbB Receptors (EGF Receptor)IBA 04/2014 - 01/2001
2	Cisplatin (Platino)FDA LinkGeneric 01/2003 - 01/2001
1	ras Guanine Nucleotide Exchange FactorsIBA 01/2016
1	GTP Phosphohydrolases (GTPases)IBA 01/2016
1	CytokinesIBA 01/2016
1	Proteins (Proteins, Gene)FDA Link 01/2016
1	Guanine NucleotidesIBA 01/2016
1	InterleukinsIBA 01/2016
1	NucleotidesIBA 01/2016
1	Biological ProductsIBA 04/2014
1	Tyrosine Kinase InhibitorsIBA 04/2014
1	Biomarkers (Surrogate Marker)IBA 03/2013
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 03/2013
1	OSU 6162IBA 06/2012
1	Huntingtin ProteinIBA 06/2012
1	polyglutamineIBA 06/2012
1	NucleoproteinsIBA 05/2010
1	Gemcitabine FDA Link 01/2003
1	Penicillins (Penicillin)FDA Link 03/2001
1	Anti-Bacterial Agents (Antibiotics)IBA 03/2001
1	Ifosfamide FDA LinkGeneric 01/2001
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2001
1	Thyrotropin (Thyroid-Stimulating Hormone)FDA Link 01/2001
1	Epidermal Growth Factor (EGF)IBA 01/2001

Therapy/Procedure

1	Therapeutics 03/2013
1	Drug Therapy (Chemotherapy) 01/2001